Peptic ulcer is break of mucosal integrity of the stomach and/or duodenum leading to local defect due to active inflammation.
Peptic ulcers can result from Helicobacter pylori infection and from drugs like NSAIDs (non-steroidal anti-inflammatory drugs) which damages lining of stomach or duodenum.
Modified Johnson classification of peptic ulcers.
Type I: Ulcer along the body of the stomach, most often along the lesser curvature of stomach. Not associated with acid hypersecretion.
Type II: Ulcer in the body of the stomach along with duodenal ulcers. It is associated with excess acid secretion.
Type III: Ulcer in the pyloric channel within 3 cm of pylorus. It is associated with excess acid secretion.
Type IV: Proximal gastroesophageal ulcer.
Type V: Ulcer can occur throughout the stomach. Associated with chronic use of NSAIDs (such as aspirin, ibuprofen).
